Clara Bourbousse

CNRS Researcher
LABORATOIRE DE BIOLOGIE DU DEVELOPPEMENT (LBD UMR7622)
INSTITUT BIOLOGIE PARIS SEINE (IBPS), SORBONNE UNIVERSITY

I received my Master’s degree in Plant Sciences from ENS Cachan - University Paris XI in 2008, and my Ph.D. in Biology from University Paris XI in 2012. 

I did my doctoral research at the Institute of Biology of the ENS (IBENS, Paris, France), which focused on chromatin dynamics during photomorphogenesis in Arabidopsis thaliana. 

Following my Ph.D., I did my post-doctoral research in the laboratory of Dr. Julie Law at the Salk Institute, San Diego, USA. My work there was centered on deciphering the regulatory transcriptional network and the involvement of chromatin components in the DNA damage response in Arabidopsis thaliana. 

In 2021, I joined the National Centre for Scientific Research (CNRS) at the Institute of Biology of the ENS (IBENS, Paris, France) to pursue exploring light-driven chromatin dynamics in Arabidopsis thaliana with Dr. Fredy Barneche and to start exploring the importance of cellular metabolism in these processes through the award of a young investigator grant from the Agence Nationale de la Recherche (ANR). 

In February 2024, with Fredy Barneche and our team members, we established the Plant Nucleus Dynamics & Signaling (PNDS) team at Sorbonne University.

EMAIL clara.richet-bourbousse@sorbonne-universite.fr 

PHONE +33 (0)1 44 27 81 18

ORCID https://orcid.org/0000-0001-6464-6124

Publications

1. Amiard S, Feit L, Vanrobays E, Simon L, Le Goff S, Loizeau L, Wolff L, Butter F, Bourbousse C, Barneche F, Tatout C, Probst AV. (2024) The TELOMERE REPEAT BINDING proteins TRB4 and TRB5 function as transcriptional activators of PRC2-controlled genes to regulate plant development. Plant Communications 2024 Apr 1:100890. doi: 10.1016/j.xplc.2024.100890.

2. Blanco-Touriñán N., Pérez-Alemany J., Bourbousse C., Latrasse D., Ait-Mohamed O., Benhamed M., Barneche F., Blázquez MA, Gallego-Bartolomé J., and Alabadí D.. (2024) Genome-wide evidence of the role of Paf1C in transcription elongation and histone H2B monoubiquitination in Arabidopsis. Plant Physiology kiae041, doi: 10.1093/plphys/kiae04

3. Godwin J., March E., Govindasamy M., Bourbousse C., Wolff L, Fort A., Krzyszton M., López J., Swiezewski S., Barneche F., Schubert D., and Farrona S. (2024) The UBP5 histone H2A deubiquitinase counteracts PRC2-mediated repression to regulate Arabidopsis development and stress responses. Nature Communications 15, 667 doi: 10.1038/s41467-023-44546-8

4. Joli N., Concia L., Mocaer K., Guterman J., Laude J., Guerin S., Sciandra T., Bruyant, Ait-Mohamed, Beguin, Forget, Bourbousse C., Lacour, Bailleul, Nef, Savoie, Tremblay, Campbell, Lavaud, Schwab, Babin, Bowler C. (2023) Hypometabolism to survive the long polar night and subsequent successful return to light in the diatom Fragilariopsis cylindrus. New Phytologist doi: 10.1111/nph.19387

5. Teano G., Concia L., Carron L., Wolff L., Adamusová K., Fojtová M., Bourge M., Kramdi A., Colot V., Grossniklaus U., Bowler C., Baroux C., Carbone A., Probst A.V., Procházková Schrumpfová P., Fajkus J., Amiard S., Grob S., Bourbousse C. and F. Barneche (2022) Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis. Cell Reports 10.1016/j.celrep.2023.112894

6. *Schivre G, *Johann to Berens P, Barneche F, ✉️Bourbousse C, and ✉️Molinier J. (2022) Advanced methods for segmentation of Arabidopsis nuclei and chromocenters. Epigenomes doi:10.3390/epigenomes6040034

7. Patitaki E., Schivre G., Zioutopoulou A., Perrella G., Bourbousse C., Barneche F. and Kaiserli E. (2022) Light, chromatin, action: nuclear events regulating light signaling in Arabidopsis. New Phytologist 236(2), 333- 349. doi : 10.1111/nph.18424 [Review]

8. Jurdak, R.; Rodrigues, G.; Chaumont, N.; Schivre, G.; Bourbousse, C.; Barneche, F; Bou Dagher Kharrat, M.; Bailly, C. (2022) Intracellular reactive oxygen species trafficking participates to seed dormancy alleviation in Arabidopsis seeds New Phytologist 234: 850-866 doi: 10.1111/nph.18038

9. Zhou M., Coruh C., Xu G., Bourbouse C., Lambolez A., Law J.A. (2022) The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis. Nature Commununications 13, 244. doi : 10.1038/s41467- 021-27690-x

10. *Cañibano, E., *Bourbousse, C., Garcia-Leon, M., Wolff, L., Garcia-Baudino, C., Barneche, F., Rubio, V., and Fonseca, S. (2021). DET1-mediated COP1 regulation avoids HY5 activity over second-site targets to tune plant photomorphogenesis. Molecular Plant 12, 3: 292-294 doi: 10.1016/j.molp.2021.03.009

11. Bourbousse, C., Barneche, F., and Laloi, C. (2020). Plant chromatin catches the sun. Frontiers in Plant Science 10. doi: 10.3389/fpls.2019.01728 [Review]

12. Fiorucci, A., *Bourbousse, C., Concia, L. Rougée M., Layat E., Zabulon G., Deton A.F., Latrasse D., Lombard B., Stroebel D., Lemoine S., Mohammad A., Blugeon C., Loew D., Bailly C., Bowler C., Benhamed M. and*Barneche F. (2019) Arabidopsis S2Lb links AtCOMPASS-like and SDG2 activity in H3K4me3 independently from histone H2B monoubiquitination. Genome Biology 20, 100 doi: 10.1186/s13059-019-1705-4

13. Bourbousse C, Barneche F. (2019) A Dynamic Signaling Path to Chromatin-Level Control of Plant Drought Response. Molecular Plant 12, 292 – 294 doi: 10.1016/j.molp.2019.01.022 [Spotlight]

14. *Nassrallah A., *Rougée M., Bourbousse C., Drevensek S., Fonseca S., Iniesto E., Ait-Mohamed O., Deton- Cabanillas A.F., Zabulon G., Ahmed I., Stroebel D., Masson V., Lombard B., Eeckhout D., Gevaert K., Loew D., Genovesio A., Breyton C., de Jaeger G., Bowler C., Rubio V., Barneche F. (2018) DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis. eLife 2018;7:e37892 doi: 10.7554/eLife.37892

15. Bourbousse C., Vegesna N. and Law J. A., (2018) SOG1 activator and MYB3R repressors regulate a complex DNA damage network in Arabidopsis, PNAS 115, 52. E12453-E12462 doi: 10.1073/pnas.1810582115

16. Bourbousse C, Benhamed M, Barneche F. (2018) Profiling Developmentally and Environmentally Controlled Chromatin Reprogramming. Methods in Molecular Biology. 2018;1675:3-30. doi: 10.1007/978-1-4939-7318- 7_1 [Review]

17. Snoek B.L., Pavlova P., Tessadori F., Peeters A.J.M., Bourbousse C., Barneche F., de Jong H., Fransz P.F. and van Zanten M. (2017) Genetic Dissection of Morphometric Traits Reveals That Phytochrome B Affects Nucleus Size and Heterochromatin Organization in Arabidopsis thaliana. G3, 7:2519-31 doi: 10.1534/g3.117.043539

18. *Bourbousse C., *Mestiri I., Zabulon G., Bourge M., Formiggini F., Koini M.A., Brown S.C., Fransz P., Bowler C., and Barneche F. (2015) Light signaling controls nuclear architecture reorganization during seedling establishment. PNAS 112, e2836-44 doi: 10.1073/pnas.1503512112

19. *Bourbousse C., *Ahmed I., Roudier F., Zabulon G., Blondet E., Balzergue S., Colot V., Bowler C., and Barneche F. (2012) Histone H2B Monoubiquitination Facilitates the Rapid Modulation of Gene Expression during Arabidopsis Photomorphogenesis. PLoS Genetics 8, e1002825. doi: 10.1371/journal.pgen.1002825

20. Castells E., Molinier J., Benvenuto G., Bourbousse C., Zabulon G., Zalc A., Cazzaniga S., Genschik P., Barneche F. and Bowler C. (2011) The conserved factor De-Etiolated 1 cooperates with CUL4-DDB1DDB2 to maintain genome integrity upon UV stress. The EMBO Journal 16, 1162-72. doi: 10.1038/emboj.2011.20